start with musical instruments - synthesizers
get an old moog and spend a lot of time tweaking the knobs and getting the sound variations in your head - envelope filters etc.
learn to do that with your vocal chords - to isolate aspects of the sound and then smoothly vary them.
make mechanical instruments that optimize or exploit the variability of each type of sound manipulation
maybe start with a trumpet with a squeezy baloon valve or section that changes the sound in the experimentally determined way that changing the shape of the vocal chords produces overtones in Overtone singing.-- JesusHChrist, Jan 15 2013 Can you explain this for the benefit of sober readers? Thanks.-- pocmloc, Jan 15 2013 I made the fartesizer-- Brian the Painter, Jan 16 2013 wind chimes that drag nails on chalkboard for you-- Brian the Painter, Jan 16 2013 It reads like a [beanangel] idea, only shorter.-- UnaBubba, Jan 16 2013 My suggestion--pick a few and develop them further so this doesn't read so much like a list off the top of your head.-- RayfordSteele, Jan 16 2013 I stuck a screwdriver into a broken electrical socket and made myself into a Van De Graaff Generator. Oh, not really the same idea.-- xandram, Jan 16 2013 Sp: vocal cords.-- csea, Jan 16 2013 [+] but just barely: I don't see much in the way of *how* to emulate an electronic analogue synth acoustically.-- FlyingToaster, Jan 16 2013 random, halfbakery