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An immunization that mimics exercise

exercise both upregulates and downregulates various chemicals circulating at the body. Immunizing against the ones it downregulates could confer some of the benefits of exercise ...without exercising
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Exercise both up regulates and down regulates the production of biochemicals at the body. It is possible finding another way to reduce the chemicals that are down regulated could have some of the beneficial effects of exercise.

One example is cholesterol. It is actually possible to immunize against cholesterol as well as down regulate it with drugs. The idea then is to make a list of other circulating biochemicals like proteins that go down with exercise and then immunize against them. I will list these proteins when I find a better internet spot. One of them is some sort of myoglobin. And here they are: BACE1, myocardial myoglobin, nitrite reductase, C/EBPβ, TNF-α. Some of these might not be circulating proteins.

Of course an oral vaccine would be great, “here drink this! It’s 2/3 as good as exercising regularly and lasts your whole life!”

beanangel, Dec 14 2017

Immunizing with cholesterol causes rabbits to have 35% less cholesterol https://www.ncbi.nl....gov/pubmed/8592095
Although the mean serum cholesterol level, mainly in the form of very-low-density lipoprotein cholesterol, rose as much as 60-fold in the nonimmunized rabbits, the elevation was significantly less--as much as 35% lower--in the immunized rabbits [beanangel, Dec 15 2017]

Immunizing rabbits with cholesterol reduces cholesterol plaques 74% https://www.ncbi.nl....gov/pubmed/8696949
Immunization with LDL and oxidized LDL reduced atherosclerotic lesions in the proximal aorta by 74% (P < .05) and 48% (P = NS), respectively. [beanangel, Dec 15 2017]

nitrate reductase and myocardial myoglobin https://www.ncbi.nl...gov/pubmed/23962643
Mice subjected to voluntary wheel running (VE) for 4weeks displayed an 18% reduction in infarct size when compared to sedentary mice, whereas mice administered nitrite therapy (25mg/L in drinking water) showed a 53% decrease. (interpreation: myocardial myoglobin causes the wrong kind of nitrate; so less is better) [beanangel, Dec 15 2017]


       I didn’t know mimics could do that.
Ian Tindale, Dec 14 2017

       No, nature is cycles apon cycles apon cycles. Aiming for a constant action is only good for an emergency procedure. It would end up a poison.
wjt, Dec 14 2017

       Are these cycles unicycles, bicycles or tricycles?
Ian Tindale, Dec 15 2017

       //unicycles, bicycles or tricycles?// With nature, all of the above and more.
wjt, Dec 15 2017

       I see. A mimic can exercise something, such as immunisation, when riding a tricycle on top of a bicycle on top of a unicycle.
Ian Tindale, Dec 15 2017

       [beany], can you reference the immunization against cholesterol? I don't see how it's possible, as cholesterol is a major component of cell membranes.   

       <edit> OK, I found articles about the immunization. It's actually against a protein involved in cholesterol processing, but I am surprised and impressed that it works! Thanks for bringing it to my attention.
MaxwellBuchanan, Dec 15 2017

       [Ian] Or learning healthy hexacycle riding.
wjt, Dec 15 2017

       I put up a couple pubmed references where cholesterol, the material, reduced cholesterol 35% and aortic lesions 74%.   

       I listed some proteins that go down with exercise as well, I do not know if they are circulating proteins though: BACE1, myocardial myoglobin, nitrite reductase, C/EBP&#946;, TNF-&#945;
beanangel, Dec 15 2017

       I would be very, very doubtful of letting anyone immunize me against myocardial myoglobin.
MaxwellBuchanan, Dec 15 2017

       Yes, but would you try it on [beanangel] ?
normzone, Dec 15 2017

       Oh, obviously, but I've already put [8th]'s hand up to be first.
MaxwellBuchanan, Dec 15 2017

       Rather than make a new junkie friend and then having them shoot me up with cholesterol liposomes there is another option.   

       Have you noticed some jewelry leaves a green mark on skin from the copper? A gooey mess of copper and cholesterol could be used to create an amulet that when worn causes a slight rash and immunizes against cardiovascular disease with an external reaction
beanangel, Dec 15 2017

       Let go of our wrist ... OW! LEGGO ! That HURTS ! That's not funny ! We're NOT volunteering ! OUCH ! Let GO ! You are going to get a right smack in a minute ... look, just make Sturton try the stuff, it's not silver or garlic or holy water, it can't harm him ...
8th of 7, Dec 15 2017

       1 ethel, 2,6 phenyl heptane looks like a bicycle. If it was 1 ethel, 2,6 ferrocene heptane it would have rotating wheels.
beanangel, Dec 15 2017

       Well, if it looks like a bicycle, and it smells like a bicycle, and it rides like a bicycle, it's probably a complex unsaturated multicyclic hydrocarbon, without proper lights, brakes or a bell, which means you can't ride it on a public road.
8th of 7, Dec 15 2017

       In the same way, you could delete a third of the attributes at random from an application's object model, and expect it still to be two thirds as useful. After all, it's not as if they interact, or depend on each other, or anything. [-]
pertinax, Dec 15 2017


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