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New medicines from plants

plants have active compounds shield some amplify the novel ones plus facilitate their membrane activity effect on a well known grocery item
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rapidly described

Make plant juice

Fractionate with chromatography

Use hydroxylase or ring opening to quiet the alkaloid

Use a ferric chloride solution with bubbled chlorine to amplify the unknown medicine

Use diacetylation or chlorophenoxyation to make the molecule pass membranes effectively

Test on motile bacteria as well as tissue culture mammal tissue

Plants contain billions of different chemicals If it were possible to screen these there would be more kinds of medicines This idea has a shielding known effect as well as an amplifying effect Shielding the known use while amplifying the new medicines creates a bandpass filter to find fresh active molecules

Alkaloids have a typical chemical structure with some plants alkaloids are there at sufficient quantities to cause noted effect from an edible dose If the ephedra plant also contained a diabetes drug as well as a sedative drug humans would only notice the stimulating ephedra effect

An alkaloid can be passivated with hydroxylase enzyme this removes –OH groups yet leaves hydrogen another possibility is a ring opening reaction

Use halogenation to amplify the nonalkaloid compounds this replaces the hydrogens with a halogen like chlorine the replaceable hydrogens remain on the molecule after the hydroxylase treatment Fluorocortisone is hundreds of times more potent than cortisone Chloroquine is much more powerful than quinine Prozac is a fluorinated variation on antihistamines that gradually makes people perky Chloromolecule has a high likelihood of having amplified medical characteristics

Going further would be availablization with diacetylation or chlorophenoxyation of the hydroxylase treated chloromolecule Diacetylation is used to make morphine to heroin as this passes membranes much better The chlorophenoxy group para to a molecule core is mid twentieth century way to get drugs to pass the blood brain barrier chlorophenoxy acetic acid is a commercial plant growth hormone

Pharmacologists often work with what they call classes of molecules I think the shield then amplify plus availablize approach could find new classes of molecules to build on

Thus

Make plant juice

Fractionate with chromatography

Use hydroxylase to quiet the alkaloid

Use a ferric chloride solution with bubbled chlorine to amplify the unknown medicine

Use diacetylation or chlorophenoxyation to make the molecule pass membranes effectively

Test on motile bacteria as well as tissue culture mammal tissue

Now my thought is that somewhere out there a thing like lawn grass will have detectable medical effect if fractionated then chloroamplified then availableized Or Orange Juice Or Algae

That Shulgin has created brominated phenyethamine known as 2-CB shows that if you brominated chocolate after passivating the theobromine plus caffeine you’d have a prosocial aphrodisiac

Traditionally people collected psychoactive drugs This may be a very simple synthesis plus detection pathway to herbal drugs that are legal as well as more attractive than current street drugs

beanangel, Jan 27 2009

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       I didn't read the text part of this idea, but are you suggesting screening plants for pharmacologically active compounds?
MaxwellBuchanan, Jan 27 2009
  
      
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