Half a croissant, on a plate, with a sign in front of it saying '50c'
h a l f b a k e r y
Compound disinterest.

idea: add, search, annotate, link, view, overview, recent, by name, random

meta: news, help, about, links, report a problem

account: browse anonymously, or get an account and write.

user:
pass:
register,


                                                       

Peptide DDT

Wikipedia says banning DDT may have killed 20 million people; PeptideDDT attaches a highly immunoreactive protein to one of the benzenes on DDT; this new kind of DDT is hyperattractive to bird n mammal macrophages thus minimizing environmental risk Epitalon with a fully chlorinated phenylalanine dimer might be the DDT workalike that if removed from the environment would make birds fish n mammals sicker thus there is a regulatory advantage to permitting Epitalon chloro diphenylalanine
  (+1, -7)(+1, -7)
(+1, -7)
  [vote for,
against]

Bill Gates Foundation is putting much effort towards a malaria cure

Wikipedia notes the human application complexity of using things like DDT to reduce disease: Robert Gwadz of the National Institutes of Health said in 2007 that "The ban on DDT may have killed 20 million children."[101] These arguments have been called "outrageous" by former WHO scientist Socrates Litsios and May Berenbaum, a professor of entomology at the University of Illinois at Urbana-Champaign, says that "to blame environmentalists who oppose DDT for more deaths than Hitler is worse than irresponsible."[79]

My appllication is just to attach a highly immunoreactive peptide to one of DDTs benzene groups such that the moment a mammalian or avian or amphibian or fish macrophage detects the peptide the peptideDDT gets immunoprocessed I'd like to say metabolized

Bugs lack macrophages thus the bugs still die from DDT

depending on the reactivity of the peptide plus the liver enzyme macrophage processing steers the peptideDDT towards there might be a thousandth the effect on animals plus preferential creation of a preferred physiologically benign organic metabolite

beanangel, May 02 2009

DDT http://en.wikipedia.org/wiki/Ddt
gorgeous molecule featuring 1,1,1-trichloro-alwayslookonthebrighsideoflife-2,2-bis(4-chlorophenyl)ethane [beanangel, May 02 2009]

a carbohydrate that alerts the immune system http://en.wikipedia...ding_lectin_pathway
[beanangel, May 03 2009]

epitalon promotes mammal longevity http://www.citeulik...nush/article/233918
[beanangel, May 05 2009]

[link]






       I don´t think this would work at all. It sounds like it would trigger anaphylaxis in vertebrates, kill them, then the DDT would be released into the environment anyway. I couldn´t swear to that but i find it hard to imagine that it wouldn´t happen.
nineteenthly, May 02 2009
  

       This is only dumb for a few reasons:   

       1) It's very unlikely that DDT will work as an insecticide if it's glued to the side of huge protein molecule.   

       2) If higher animals ingest your protein-DDT (or did you mean peptide-DDT?), and if they do degrade the protein component, you'll be left with a DDT molecule with a few amino acids glued to it. I wouldn't be at all surprised if it were as toxic as DDT, and probably harder for the body to eliminate.   

       3) DDT is good because it's cheap and stable. DDT coupled to a protein will be expensive and unstable (aside from the fact that it won't work).   

       This is once, twice, three times a lame idea.
MaxwellBuchanan, May 02 2009
  

       I was thinking yall would suggest putting a hydrocarbon effect separation molecular spacer between the peptide /\/\/\/\/\ DDT That is how they attach fluorophores to small drug molecules to preserve small molecule function while finding their sites of action with fluorescence   

       [MB] There are numerous peptides engineered to pass the GI tract I've read references about this   

       I am thinking that the particular peptides amino acids might cause the entire molecule to be associated with distinguishable p450 liver enzymes such that the products are metabolized if I may use that word to specific known chemicals
beanangel, May 02 2009
  

       //a hydrocarbon effect separation molecular spacer// You mean a linker. Yes, so what? It's still unlikely that DDT is going to work like DDT when it's tied to a protein.   

       //There are numerous peptides engineered to pass the GI tract I've read references about this// There are indeed, and I'm sure you have. So what?   

       //I am thinking that the particular peptides amino acids might cause the entire molecule to be associated with distinguishable p450 liver enzymes such that the products are metabolized if I may use that word to specific known chemicals// Gibber gibber gibber.   

       Beany, beany, beany - as I've said before, if you can't filter the input, at least filter the output.
MaxwellBuchanan, May 02 2009
  

       for crissake take a chem class.
WcW, May 02 2009
  

       Despite the prevailing opinions, it's a nice thought.
phoenix, May 03 2009
  

       why aren't there more amateur chemical engineers?
WcW, May 03 2009
  

       Ah yes, lots more scavenging of outputs.In fact, a new ecosystem would do nicely.
wjt, May 03 2009
  

       [WcW], there are probably quite a few, it's just that they work in rather clandestine but profitable areas, often involving imports from Columbia. People just need to be "correctly" motivated.
nineteenthly, May 03 2009
  

       //why aren't there more amateur chemical engineers?// Natural selection.
MaxwellBuchanan, May 03 2009
  

       and the desired metabolic pathway is.....
WcW, May 03 2009
  

       If we can figure out a DDT replacement Wikipedia notes that Mosquitoes are estimated to transmit disease to more than 700 million people annually   

       Here is a clownish speculation you may like   

       ethidium bromide is known as a DNA attaching agent; it is also a pesticide   

       from the structure it appears ethidium bromide can be both hyperchlorinated to act like ddt plus you could have a peptide on it that would preferentially attach to naughty dna like the common cold virus dna This would create a pesticide that also reduced the transmission of the common cold   

       this clownish speculation has a useful idea though are there any organochlorine compounds that are generally beneficial to humans If there are then modifying these beneficial compounds to be insecticides creates a multiple benefit   

       I'm under the impression that there are halogenated aspirin derivatives; just possibly there is an insecticide that reduces cardiovascular disease   

       Methoxychlor is basically DDT with OCH3 it had a lot going for it but was phased out 2003 Its possible that a DDT-CHO carbohydrate would be unusually susceptible to vertebrate metabolism while being a strong insecticide Mannose-DDT appears to have a high likelihood of being rapidly immunoscavenged plus having activity kind of like DDT or methoxychlor   

       Any ideas readers have on vertebrate beneficial insecticides here 700 million people annually staying well from a truly beneficial insecticide is a bunch
beanangel, May 03 2009
  

       //If we can figure out a DDT replacement Wikipedia notes that Mosquitoes are estimated to transmit disease to more than 700 million people annually // Oh, right. Jolly good idea, we must go and advise the chemists that we have a new project for them.   

       And this year's award for Utter Bollox goes to.......
MaxwellBuchanan, May 03 2009
  

       every single one of bean's ideas has a tinge of WIBNIfty to it. Wouldn't it be nice if science worked really well and was easy and simple and anybody could grasp it simply by reading abstracts.
WcW, May 04 2009
  

       That DDT molecule is nifty. Fearful symmetry. But suppose it did have a peptide thinger and a macrophage grabbed it. Could it hold it? DDT is fat soluble. I suspect the macrophage would be able to bust up the peptide, or the attachment piece, and then the DDT would wander back out through the cell wall en route to some nascent eggshell.
bungston, May 04 2009
  

       [bungston] I appreciate the nifty science thoughts   

       while I ponder what you say what do you think of this idea Attach the 4 amino acid longevity peptide epitalon to a fully chlorinated phenylalanine dimer (two phenylalanines looks like DDT) to create a insecticide that actually makes vertebrates live longer   

       The regulatory advantage of epitalon DDT is that if it were removed from the environment fewer birds fish n mammals would live than if it were present   

       The point of killing the bugs being rescuing 700 million people from mosquito sickness each year   

       technology: make phenylalanine dimers then chlorinate with chlorine plus ferric chloride then attach to eptalon peptide with a condensation reaction
beanangel, May 05 2009
  

       //every single one of bean's ideas has a tinge of WIBNIfty to it// What about the iodised ink? That looked OK to me. Post-it notes which change colour as they get more urgent? Also good.
nineteenthly, May 05 2009
  

       2 polychlorinated aromatic rings sounds like polychlorinated biphenyl. I am not sure how a chemical would make vertebrates live longer.
bungston, May 05 2009
  

       //Attach the 4 amino acid longevity peptide epitalon to a fully chlorinated phenylalanine dimer (two phenylalanines looks like DDT) to create a insecticide that actually makes vertebrates live longer//   

       Beany, beany, beany - dumb, dumb, dumb. Different molecules behave differently. Thalidomide happens to look like guanine fused to thymine - both vital components of that Jolly Good molecule, DNA. I have seen clouds that look a bit like wallabies. I even know a woman who has a mole that looks like Cyprus (though not as large).   

       If you're interested in chemistry, molecular biology and suchlike, then there are lots of quite good books on the subject. Bless.
MaxwellBuchanan, May 05 2009
  

       I think even a seasoned chemist would create a group of related molecules then measure them I think DDT-mannose as well as Epitalon DDT are of value   

       DDT is different than a PCB even though it is literally a polychlorinated dibenzene   

       epitalon is published as being active at microgram quantities, which weirds me out a little   

       anyway I put up an epitalon link   

       Mosquitos are thought to feed so they get protein to lay eggs, its possible there is a chemical that tells mosquitos they have sufficient protein even absent feeding, it might be a satiety peptide   

       as easy as I may be to criticize I urge you people to think a little on a new insecticide that cures malaria   

       If we were really going to creative though we would think of a way to transcend the quality of government. Its quite possible that if the afflicted regions had what I think of as near functional governments methoxychlor could have been used to eradicate malaria   

       I think the Gates foundation likes malaria treatments as sick people are more likely to seek a cure than governments are to be competent
beanangel, May 05 2009
  

       //easy as I may be to criticize I urge you people to think a little//   

       The problem, Beany, is in your signal to noise ratio.   

       You have a habit of saying "Look what I've just read" and then extrapolating without a licence. Not all of your ideas are dumb, but you affect this peculiar writing style, which is recognisable but makes it like trying to read with one eye tied behind your back. Also, if you are extrapolating far enough to get from A to Z, you would often to better to think about starting from X or Y instead, or at least learning the rudiments of B through Y.   

       The world is full of truly amazing facts. The skill is not in finding an amazing fact and jumping from there to your goal. It is in (a) finding amazing facts which are also likely to be correct and (b) finding a plausible [even by HB standards] way of getting from there to your goal by ground instead of by air.
MaxwellBuchanan, May 06 2009
  

       In his defense, bean's ideas are always halfbaked as according to the HB charter, in that every single one is a poorly thought out idea for an invention. Each has a germ of science. All seem generally without malice and intended to benefit humanity. Beany is quite durable as regards ad hominem attacks. I admit that I saw red for the briefest instance the last time I found one of my annos deleted and repasted, but then I remembered it was just the Halfbakery, which is for fun.
bungston, May 06 2009
  

       Believe me, I would miss our Beany. But his ideas need more filling in between the bit that goes "scientists have recently simulated the distribution of matter in a model universe" and the bit that goes "could reduce the risk of catching bad smallpox from handyphones"
MaxwellBuchanan, May 06 2009
  

       Simply saying "I think that adding a "peptide" to DDT could make a better pesticide" without recognizing that the smallest synthesized peptide is hundreds of times more massive than a diphenol and that this would be the rough equivalent of attaching a rubber dinghy to an aircraft carrier.   

       Complete lack of functional understanding.   

       Would attaching a DDT molecule change the properties of a peptide? Maybe, depending on which of the thousands of places you put it, but I doubt that this final molecule would be an insecticide.   

       The idea isn't just comical, it is completely ludicrous, and shows a completely superficial understanding of the scientific vocabulary it contains. A "snow job" so to speak.
WcW, May 06 2009
  
      
[annotate]
  


 

back: main index

business  computer  culture  fashion  food  halfbakery  home  other  product  public  science  sport  vehicle