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Uncyclopedia

Book of things that we don't know yet
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Being bombarded by so much progress, technology and specialization it often feels like that there is not much interesting science left to discover (other than perhaps some obscure scientific curiosities, or things requiring exotic scientific apparatus to study)

Uncyclopedia is collection of all important questions that do not have a satisfactory scientific answer yet. It is important to note that it's written in a approachable manner that doesn't demand specialization in the field to understand (just like an encyclopedia)

When I was a kid I was fascinated by the concept of "white" undiscovered areas on a map. When I grew up and realized that thanks to satellites, most of the world has been mapped in great detail. I was disappointed. That is only after I stumbled across additional "white" regions in our collective knowledge.

Instead of stumbling across them randomly, uncyclopedia is a curated list of these far off undiscovered lands.

ixnaum, Jun 17 2021

Uncyclopedia entry on "knowledge" https://uncyclopedia.ca/wiki/Knowledge
[pocmloc, Jun 18 2021]

[link]






       I'm not sure the sea floor has been mapped in full. Especially not in the Arctic.
RayfordSteele, Jun 17 2021
  

       Huh, I like this a lot.   

       When I was an undergraduate, professors would frequently give advice about exams: "Answer the question, don't just write down what you know". Which is good advice, except they don't follow it themselves, papers & textbooks are full of what we DO know and are spectacularly bad at highlighting gaps or open questions. I've been a research scientist for over a decade now and in my specific area of interest, I can tell you a lot of what we don't know. I'm missing things though, and in other disciplines, I haven't a clue. Physics is much better at this, they have fewer opportunities to experiment and lots more time to refine questions.   

       A book of what we don't know would be a real treat to read. I could do a section on mitochondria if you like:   

       Mitochondria tethered physically by proteins to other organelles like the endoplasmic reticulum. We don't know how many different proteins are involved and only have vague clues as to the identity of one of them, maybe.   

       Mitochondria undergo fusion and fission. We don't know anything about the machinery that divides the inner membrane into separate compartments. No idea at all.   

       Mitochondria squirm about randomly inside cells, we know what stops them (calcium and oxidation) but we have no idea why they bother in the first place.   

       Despite decades of measurements and multiple techniques, we're not sure what the actual concentration of calcium (ionized or otherwise) ranges to inside the mitochondrial matrix.   

       Mitochondria randomly depolarize, then, turn back on. We have no idea why.   

       In some cells, mitochondria align their cristae perfectly with the adjacent mitochondria. No idea why.   

       The outer mitochondrial membrane is full to bursting with proteins called "Voltage-dependent anion channels". They are, as the name suggests, functionally dependent upon voltage/membrane potential. Yet, no-one has measured a Voltage, and calculations suggest it's not possible to generate a sufficiently high Voltage to affect the protein, so what's going on?   

       Some non mitochondrial stuff: Intracellular Ca2+ release is a fundamental signaling mechanism conserved in most eukaryotic life. There are thousands of Ca2+-regulated proteins in almost every conceivable pathway and a complex system of buffers/channels/pumps & exchangers to organize it. Yet, you can knock out 3 proteins required for Ca2+ release, and the cells live + grow just fine. What's going on there?   

       There should also be a large section in the Uncyclopedia on the placebo effect.
bs0u0155, Jun 17 2021
  

       Unfortunately, there are 2 "groups" of things we don't know:
1: Things we KNOW we don't know
2: Things we DON'T know we don't know
This book only covers group 1, as there is no way to collect group 2.
neutrinos_shadow, Jun 18 2021
  

       you're missing the known knowns, and the unknown knowns.
bs0u0155, Jun 18 2021
  

       I like it. Some questions:
1. Is it possible to actually build a cannon big enough to launch stuff into orbit? Specifically (learning from Project Babylon), is it politically possible for the lead engineer to survive long enough to finish the project?
2. What is the answer to the hard problem of consciousness? In other words, why am I not simply a meat robot without conscious awareness? In other words, what if anything will I experience after physical death? Is this scientifically testable?
3. Is it possible to actually build a self-replicating robotic mining and manufacturing operation that would consume terrain and turn it into machinery, with a net-positive efficiency? (i.e. the tooling will last long enough without wearing out to produce more than one complete copy of the machinery?) What is the mass and cost of a somewhat well- optimized system of this type, and what is a financing structure that would enable building one and dropping it from orbit onto Mars?
4. Is it possible to use an optical system to perform quantum computations substantially faster than a digital computer simulation of the quantum process? Specifically, by using some polarizing filters and delay lines to create laser beams with electronically controllable amplitude and phase, then adding those together, then using a camera and interference with a reference beam to sample the amplitude and phase of the beam and store it in computer memory...could this run quantum algorithms? (My guess is that it's not useful unless it can store and add actual qbits i.e. complex-valued memory elements, due to resolution limits inherent in trying to produce a laser beam that matches the state of some qbit stored in computer memory, but I have not checked this.)
5. Does modern communication technology (a natural monopoly) inevitably lead to a single globe-spanning monopoly? (Think a cable telecommunications monopoly, but everywhere.) Is this a realistic concern, and if so is there other technology that would shift the equilibrium in a different direction or at least prevent regulatory capture? Specifically, is there a way to combine cryptocurrency mining, secure hardware, and mesh networks, to make a new internet that pays users a monthly dividend?
6. Does real life follow some set of narrative rules in addition to the physical laws? How can I distinguish between luck, divine intervention, and madness? How can I reach the frontiers of human experience?
sninctown, Jun 18 2021
  

       //1: Things we KNOW we don't know //2: Things we DON'T know we don't know   

       When a thing goes from 2->1 sometimes that's very significant.
ixnaum, Jun 18 2021
  

       I wonder if this project could spiral uncontrollably, in that the process of compiling known unknowns generates a faster transfer of unknown unknowns to known unknowns than of known unknowns to known knowns.
pocmloc, Jun 18 2021
  

       + super! this should also include things that we think we know but are definitely wrong! or possibly wrong. You know how they find out 20 years later that they were wrong about some thing…
xandram, Jun 18 2021
  

       //When a thing goes from 2->1 sometimes that's very significant.//   

       You can get funded for 1.   

       //things that we think we know but are definitely wrong!//   

       Which is likely an awful lot. Again, physics is ahead of the crowd on this one. Relativity is neat! Doesn't explain small stuff though, so is definitely a bit wrong. Quantum physics is neat, doesn't explain big stuff though, so definitely a bit wrong. Galaxies are neat, but we don't know what 95% of them is, just the shiny bits.
bs0u0155, Jun 18 2021
  

       sample Uncyclopedia entry on STORY:   

       Everything is made of stories. DNA is a story. Every thing is telling a story to itself through others' stories. Even the stories tell stories. Buncha physicists recently (re)discovered that the Universe is conscious(ness). Whatever is outside of the Universe is also conscious. When you die, you are not gone as long as you are part of a story.   

       [addition to the entry for HBers Edition] Douglas Adams, Sir PTerry, [Max], [8th] are part of this feedback loop from the other side of the Möbius Strip of Time.   

       Three Universal Laws of Uncyclopedia* (all true entries will conform to these laws and be internally consistent):   

       1. Paradox [eg: All colours combined equal both black and white: black (combine all the colours...of pigment) = white (combine all the colours...of light). Ha. Hmm.]   

       2. Humour [the tickly, life-affirming not-funny/funny 'Hmm' and 'Aha, interesting' kind, not the 'Ouch' kind which is funny/not-funny]   

       3. Change [eg: the more things change, the more they stay the same. Aha, true. Change reminds me of the Buddhist hotdog cart joke**.]   

       *Paradox, Humour and Change are the Three Universal Truths. Corollary: If a proof is not beautiful, it is not true. Discuss.   

       **short version: $5 hotdogs. Customer asks Buddhist monk hotdog vendor to make him 'One With Everything', ha ha' and pays with a $20. Gets hotdog, no change for the $20. Monk says 'Change comes from within'.
Sgt Teacup, Jun 18 2021
  
      
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