Half a croissant, on a plate, with a sign in front of it saying '50c'
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colostomy wine oh

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I don't know for a fact that people who destroy their liver with an alcohol addiction end up needing to utilize a colostomy bag with a catheter but I like to imagine that they do, or will need one. So this is for those poor souls that drink too much and then end up needing a colostomy bag.

This is a box of wine who's wine bladder once emptied can be re-purposed as a colostomy bag. The drinker that is hell bent on dying from scerosis may select Colostomy Wine Oh wine as their liver destroying beverage of choice all the while stockpiling the empty multi purpose bladders for a rainy day potentially enabling them to offset a portion of the medical cost of their end game.

I am thinking that this is a new category of product that falls between euthanasia aids and exercise equipment. I believe that somehow electronic cigarettes could be engineered to re-purpose as a trakyotomy kit for people who may be working on developing throat cancer or are planning an esophageal collapse. There is opportunity to stand on new ground and develop many innovative devices in this category.

vfrackis, Aug 13 2014

Alcoholic enema http://en.wikipedia.../wiki/Alcohol_enema
Sherry ... ? [8th of 7, Aug 15 2014]

[link]






       Or not.
normzone, Aug 15 2014
  

       Please Improve: 1. Spelling 2. Punctuation 3. The veil in front of your contempt.
bs0u0155, Aug 15 2014
  

       Please improve: 1. Intention 2. Purpose 3. On how you spend your time.
blissmiss, Aug 15 2014
  

       excellant lingk   

       bliss its hard to type everything correctly from a phone while riding a bumpy bus i was happy that i was able to get the idea posted at all }the only contempt embodied in my post is for correct spelling and punctuation{   

       i was inspired by the idea of "sin taxes" which i believe are unfair. That said why shouldn't multi- purpose self destruction tools exist? self destruction tools exist already - cigarettes, alcohol, a car that exceeds the speed limit etc.. I am merely suggesting delivery in a format that has some altruistic properties embodied.
vfrackis, Aug 15 2014
  

       I work in alcohol research. Alcohol does very little to the liver, directly. It messes up the Ca2+ signaling a little, but then it just compensates and everything is fine. With isolated hepatocytes you can keep winding up the ethanol until you get unrealistic levels that wash away the membranes. Nothing happens. It's a major problem in research. Yes, cirrhosis is preceded by years of alcohol abuse, but years of alcohol abuse usually does very little to the liver. Usually, most get off scot free. We can't even make a reliable animal model.   

       My pet theory is that major alcoholics don't eat (thymine deficiency and others attest to that). They intake all their calories in the form of ethanol-acetoacetate. Which sort of sneaks into the Kreb's cycle under the regulatory radar. Somehow, the liver has to back-convert that to glucose or the blood will become depleted and the brain will stop working so well.   

       I think there's a lot of metabolic workload there, and a short circuit of regulatory systems. Also, metabolic addiction to acetoacetate in peripheral tissues.
bs0u0155, Aug 15 2014
  

       Fascinating … so does the NAD/NADH cycle preserve its integrity ? What's the tradeoff between serum glucose and the ethanol- acetoacetate energy input ? Does it deplete the glycogen reserve?
8th of 7, Aug 15 2014
  

       NADH goes WAY up, it's a problem. Insulin gets stimulated, so glucose down, Glycogen down.
bs0u0155, Aug 15 2014
  

       <Stops. Re-reads [8th]'s anno. Scratches head. Looks funny at [8th].>
MaxwellBuchanan, Aug 15 2014
  

       <Looks funny at [MB]>   

       <De Niro>   

       "You lookin' at me ?"   

       </De Niro>   

       You think you're the only one with a passing aquaintance with biochemistry ? We almost had to work for that Nobel prize, you know.   

       // Insulin gets stimulated, so glucose down, Glycogen down //   

       Eh ?   

       <baffled>   

       Type II diabetes ? Elevated insulin depletes glycogen ? Elevated NADH, OK … then the acetaldehyde needs to be processed out … going to be a net energy defecit, shirley ? With elevated insulin, serum glucose will crash unless the patient is insulin-resistant …
8th of 7, Aug 15 2014
  

       Yeah. So Type 2 DM is a survival trait / protective adaptation. Who'da thunk it, eh?
lurch, Aug 18 2014
  

       A more immediately and universally useful beverage would be packaged in a douchebag or enema bag.   

       The wry attempt at humor would point out that many people deserve to be called the former and many people are full to the point they would benefit from the latter.   

       Branching out, however, there is a long tradition of medicinal teas and infusions being administered by methods other than drinking. I wonder if something like this is already done in those alternative health places.
bungston, Aug 19 2014
  

       8th   

       Alcohol feeds pretty much directly into the Kreb's cycle. Ethanol>(ADH) Acetaldehyde >(ALDH2) Acetate >(ACSS2). The net result being water, CO2 and lots of NADH.   

       The insulin will depress glucose only until it is sensed as low. Feedback is everything in biology. Then you have a demand for glucose. The liver's job. This is where I* think the problem lies. You have lots of energy streaming into the liver under the regulation radar (acetate), then a demand from the rest of the body for glucose. So you have acetate arriving, some going into the Kreb's cycle, and some going to gluconeogenesis via pyruvate.   

       Gluconeogenesis doesn't use NADH though, and the mitochondria are a bit redundant. A very dysregulated energy metabolism.   

       *personal hypothesis only
bs0u0155, Aug 19 2014
  

       Um, I think it's an electrical problem. (Hits with hammer again). Yep. Definitely an electrical problem.
RayfordSteele, Aug 19 2014
  

       // self destruction tools exist already - cigarettes, alcohol, a car that exceeds the speed limit etc.. I am merely suggesting delivery in a format that has some altruistic properties embodied.   

       I bet you're fun at parties.
the porpoise, Aug 19 2014
  

       No, he hasn't mentioned home-made pyrotechnics yet.   

       // Gluconeogenesis doesn't use NADH //   

       Er, no, NADH -> NAD is energy-negative, shirley ? Somewhere or other that's going to deplete glucose. The acetate's produced at the expense of generating NADH so it's a zero-sum game.   

       <scuttles off to re-read notes>
8th of 7, Aug 19 2014
  

       The whole process is definitely not energy negative. My personal adipocyte collection will attest.   

       The NADH normally feeds the mitochondria. Which are the most important thing in the universe apart from calcium signaling. The problem is that mitochondria use the NADH when there's an ATP demand (a calcium signal usually). Here, we're in an odd situation of having a GLUCOSE demand, an odd cart-horse scenario.   

       Also, lots of NADH and no ATP demand is a recipe for mitochondrial reactive oxygen species. ROS are the third most important thing behind calcium signaling and mitochondria.
bs0u0155, Aug 19 2014
  

       I think another tricky thing about etoh is that, as opposed to larger fats, you can't plug a 2-carbon molecule into gluconeogenesis and make glucose out of it. Folks on ketogenic diets have demand flor glucose two but you can rejigger those larger molecules and make them into glucose - not alcohol.
bungston, Aug 19 2014
  

       Animals can't make glucose from fatty acids. I'm buried in Stryer right now trying to work out how the hell alcoholics generate blood glucose.
bs0u0155, Aug 19 2014
  

       //So you have acetate arriving, some going into the Kreb's cycle, and some going to gluconeogenesis via pyruvate. Gluconeogenesis doesn't use NADH though, and the mitochondria are a bit redundant. A very dysregulated energy metabolism.//   

       And on the other side of the intellectual spectrum, today I posted an idea to stick balloons together to make a floating Mario.   

       Did I spell intellectual right? It looks wrong for some reason.
doctorremulac3, Aug 22 2014
  

       //how the hell alcoholics generate blood glucose// There'd still be sugar/carbs left over, after the yeast dies from alcohol poisoning: beer and wine aren't particularly diet-friendly. No ?
FlyingToaster, Aug 22 2014
  

       I keep reading the title as "colostomy wine oh".
MaxwellBuchanan, Aug 23 2014
  

       //There'd still be sugar/carbs left over, after the yeast dies from alcohol poisoning: beer and wine aren't particularly diet-friendly. No ?//   

       They're not diet friendly, no. My point is that there are plenty of alcoholics in the world who survive for extended periods of time, weeks, with no real food input, just vodka. If there isn't a viable mechanism for ethanol>glucose then they must derive all their blood glucose from amino acids stripped from muscle.
bs0u0155, Aug 26 2014
  

       //I keep reading the title as "colostomy wine oh".//   

       Funny how the eye plays tricks on you when you gloss over something quickly. I too thought that's what it said when I first read it but haven't had time to go back and read what it actually said.
doctorremulac3, Aug 26 2014
  
      
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