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Cohesin based birth control

Cohesin sorts sister chromatids modifying cohesin produces autoabortion of blastocysts
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This is a male based form of birth control that could also prevent birth defects and be used to have only daughters.

Note, you know how on chromosome maps the like chromosomes line up.

Well cohesin is like the rubber band that sorts the sister chromatids during meiosis.

Any change to the affinity of this protein to chromatids causes them to sort the wrong way with 2^23 possible recombinations during meiosis the odds of creating a functional gamete are trillions to one.

When the scrambled gamete meets the egg there is an absence of pregnancy

siRNA drugs could affect cohesin, as could little organic molecules. They guy takes a pill, perhaps monthly, or perhaps gets an implant (siRNA)

cohesin antibodies or a cohesin antibody producing virus are technologies but iffy as cohesin is intracyte and away from the circulatory system. A virus could produce siRNA cohesin drugs though.

likewise a cohesin with stronger affinity could reduce birth defects or be used to exclude the y chromosome to produce only daughters

beanangel, Sep 18 2009

cohesin http://www.ncbi.nlm...log$=pmtitlesearch4
During meiosis, cohesin is required for the establishment and maintenance of sister-chromatid cohesion, for the formation of the synaptonemal complex, and for recombination between homologous chromosomes. We show that REC8 has an essential role in mammalian meiosis, in that Rec8 null mice of both sexes have germ cell failure and are sterile. [beanangel, Sep 19 2009]

[link]






       I clicked on the title fully expecting to see a beanangel idea.
neelandan, Sep 19 2009
  

       What worries me about this is that cancer cells have unusual chromosome numbers, though i think they're generally polyploid. I can't help thinking this might be a way of coming up with new kinds of hydatid mole or sexually transmitted tumour.
nineteenthly, Sep 19 2009
  

       I edited out the P word [MB]wrote an item similar to   

       WcW - it is 'cohesin' - the name of a protein.   

       Beany Baby - this is probably your most stupid idea for some time, and that is indeed a not insignificant accomplishment.   

       For one thing, if you start buggering about with one of the key proteins of chromosomal segregation, you will probably have an abortifacient which is 100% efficient, since it will kill the mother.   

       For another, even if you can get antibodies into the relevant cells (and how do you   

       (go about)   

       to do that? most cells don't take up antibodies; oocytes almost certainly don't), they'll be proteolysed faster than you can say "happy sugar causes handyphones". If you want to create a virus which infects the cell and then creates an intracellular antibody, I think that's fairly far out.   

       You might as well pick any of a thousand proteins that cells need in order to survive, and   

       (go about)   

       to do that? most cells don't take up antibodies; oocytes almost certainly don't), they'll be proteolysed faster than you can say "happy sugar causes handyphones". If you want to create a virus which infects the cell and then creates an intracellular antibody, I think that's fairly far out.   

       You might as well pick any of a thousand proteins that cells need in order to survive, and (go about) knocking them out as a means of abortion. In fact, sulphuric acid has more merits than this idea, as an abortifacient.   

       This is a moronic idea and, whilst I am not one to stoop to ad hominem attacks, I think you're a complete and utter moron with verbal diarrhea. Nothing personal. — MaxwellBuchanan, Sep 19 2009
beanangel, Sep 19 2009
  

       [MB] writes   

       "I am in your debt for the editing, Beany, and I am happy to give you credit for the errors introduced thereby.   

       What's with   

       (deleted word) as a word? — MaxwellBuchanan, Sep 19 2009 "
beanangel, Sep 19 2009
  

       And the answer is? I'm curious as to whether it's an affectation and, if so, what you believe the point to be.
MaxwellBuchanan, Sep 19 2009
  

       [beanangel] please don't edit the texts. I would have thought you would have been strong enough to wear any say given. My reading is not that strong and this doesn't help.
wjt, Sep 20 2009
  

       //whilst I am not one to stoop to ad hominem attacks, I think you're a complete and utter moron//   

       sp. "source of harmless and sometimes stimulating entertainment, whom some of us would miss if he/she/it stopped posting, or returned to the mothership in a fit of pique".
pertinax, Sep 20 2009
  

       That too. And?
MaxwellBuchanan, Sep 20 2009
  

       And do something about that stoop.
pertinax, Sep 20 2009
  

       There are a lot of people on here who are a bit odd.
nineteenthly, Sep 20 2009
  

       //There are a lot of people on here who are a bit odd//
Yes, but most of us don't advertise it quite so openly...
neutrinos_shadow, Sep 20 2009
  

       I think the word is exhibit, not advertise. Advertisement suggests it's done deliberately.
nineteenthly, Sep 21 2009
  

       Wow, I don't understand any of this but I am intrigued by something that is sooo bad that it gets [MB] angry. I especially liked:   

       //you will probably have an abortifacient which is 100% efficient, since it will kill the mother//   

       and the idea that there were other things he said that were so bad they had to be edited and edited in weird ways.   

       All I can say is [beanangel], you are obviously very intelligent, but you seem obsessed with finding larger and larger atomic bombs to kill mosquitoes as many of your solutions seem worse than the problems they attempt to solve.   

       I would love to read (thru a video link, no way I'd be in same room) the warning label if any of these products which went to market.   

       "And please contact a physician if you experience any of the following symptoms: sleeplessness, headaches, explosive diarrhea, vaginal tumors, blindness, rapid aging, vaginal closing, penis growth, genetic mutations or a slow painful death."   

       PS Anyone know a medical term for someones vagina just sealing up/healing over? Like Barbie syndrome or something?
MisterQED, Sep 21 2009
  

       //sooo bad that it gets [MB] angry// I'm tolerant of most things. In fact, there's only two things I hate: generalization, and all of Beany's ideas.
MaxwellBuchanan, Sep 21 2009
  

       Perhaps you should simply avoid reading, or commenting on beany's ideas.   

       They often strike me as some odd cross-breed between an imperfectly translated haiku and a medical journal, and not very much like a typical halfbakery idea, but that's no reason for me to declare beany mentally incompetent.   

       Considering your predisposition to spot disaster in even the most mundane technological achievent, I'm surprised the both of you have existed here together at all.   

       While I see certain drawbacks to this idea, I've noticed that MB is wont to declare every HB idea a disaster, and frankly, if the two of you can't get along, I'd vote MB off the island, because I'm sick of hearing "You'll make the house collapse by putting in one of those!" every time I have a new door idea.
ye_river_xiv, Sep 22 2009
  

       I have to say that i also tend to think a lot of HB ideas would be disastrous in real life, so it's not just [MB].
nineteenthly, Sep 22 2009
  

       Half-baked: adj. Only partly baked. Informal. Insufficiently thought out; ill-conceived: a half-baked scheme. Informal. Exhibiting a lack of good judgment or common sense: a half-baked visionary.
egbert, Sep 22 2009
  

       [ye] I think the point you're failing to take into consideration is that I'm a miserable old curmudgeon. When you view my comments from that baseline, you'll see that they are generally quite positive. Besides, the house might very well collapse.
MaxwellBuchanan, Sep 22 2009
  

       //I'd vote MB off the island// Thank God this isn't reality TV... nor reality. The island is big enough. And none of us will win the grand prize.
pertinax, Sep 22 2009
  

       I thought it was an upright prize?
Ian Tindale, Sep 22 2009
  

       What is the link for? the article is not about cohesin, but about a genetics study related to one component of it.   

       As to the idea: I am not sure whether [beanangel] understood the function of cohesin, yet the question may be immaterial. The level of solutionativeness in the idea is rather low, and is not lowered by abstracting the idea to 'targeting vital systems may prove fatal'.
loonquawl, Sep 22 2009
  
      
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