h a l f b a k e r y"It would work, if you can find alternatives to each of the steps involved in this process."
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Hand-entering DNA sequence into a computer -- be it for
ordering oligonucleotides, editing sequence reads, &c. -- is
an
error-prone, tedious and slow fine-motor process. Moreover,
standard keyboards irregularly array the relevant characters
(A,C,G,T, ambiguity codes, and maybe I/U). The
task
cries out for a dedicated solution, along the lines of the
handy numeric keypad.
Enter Simon. Yes, that classic 1970s piece of bleeping,
flashing, colorful button-pushing, memory-wracking
electronic
fun. Simon came in both big tabletop and little handheld
chassis forms; both sported four big, easily distinguished
buttons, with informative light and sound feedback -- and
both
were made specifically for entering and distinguishing
strings
with a 4-letter, primary-color-mapped alphabet. What a
great
format for DNA sequence entry!
With one of its mode switches converted to activate
intuitive multi-button ambiguity code entry (like the
multiple exposure
switch/button on some SLR cameras), Simon's fairly simple
circuitry can likely be gutted/adapted to route input
through
a cable to a computer. To that end, please note that this
idea is a-half-bakin' as I write: my partly-built prototype
(using a
handheld Simon) has been lying on an engineer friend's
workbench for a few months. Simon says 'finish me'...
For anyone who wants to read the absent anno
https://web.archive...ce_20entry_20device It's worth it! [notexactly, Dec 19 2018]
[link]
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Now there's an idea. What would the Human Genome sound like if played through a Simon Says? I'm having flashbacks to the end sequence of "Close Encounters of the Third Kind" now... |
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Think of the melodies that would be produced on a Simon SMS wristwatch. |
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"We're sorry, you did not get the sequence right. Your child is going to be a chimpanzee..." |
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O.K. given Music, DNA inspired Architecture? |
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Its makes no anti-sense to me. |
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Don't know if I should add my two sense of hearing. |
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Musically coded information... now why didn't I think of that? |
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I'm going to vote for this cos of ravenswoods anno. It really ough to work like that, oughtn't it?
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Ahh, the euphony of 1/f noise, wherever it appears in
nature... Meanwhile, [riposte], message received -- now
code-on, you crazy diamond!... |
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Superb, ravenswood. Ough-inspiring, even. |
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I'm going to vote for this cos of ravenswoods anno. It really ough to work like that, oughtn't it? |
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