h a l f b a k e r y
Point of hors d'oevre
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Increasing evidence suggests that oral bacteria are linked
to diverse health problems. Obvious examples include
tooth decay and gingivitis. More interesting is evidence
demonstrating that bacteria enter the bloodstream and
turn up in odd places. Recently, Porphyromonas gingivalis,
forsythensis, and Prevotella intermedia were
shown to be present in sinovial fluid of rheumatoid arthritis
patients, and an animal study showed P.gingivalis in the
brains of Alzheimer's model mice, where they induce an
immune response that includes amyloid beta proteins.
The mentioned bacteria are all obligate anaerobes that are
intolerant to oxygen. The level of intolerance varies but
most start having a bad time at 8% or so, a little less than
half the standard atmospheric concentration. Now,
obligate anaerobes aren't just intolerant to O2, diverse
oxygen-derived molecules and powerful oxidants of all
kinds are similarly or more toxic. Humans, by contrast, are
pretty good at dealing with oxidants.
Now we may form a rationale whereby dangerous
anaerobic bacteria may be limited by deliberate
application of oxidizing equivalents to the general mouthal
environs. Traditionally, mouthwashes and toothpastes
focus on alcohol, fluoride and detergents to do their work.
Alcohol can be metabolized to dangerous intermediates by
anaerobes, fluoride is a glycolysis inhibitor and good at
stabilizing calcium deposits like teeth and the calculi that
build upon them and SDS solubilizes anything hydrophobic
it encounters. Nothing specifically aimed at anaerobes
there, as they're mostly hiding out of range.
To counter that, let's build an aggressive aerobic outreach
program to reach the parts others cannot. I propose a 2
part system of nice sounding chemicals, namely ascorbate
(vitamin C) and menadione (vitamin K3). Ascorbate has a
friendly reputation as an antioxidant, however, in an
environment of normal oxygen concentration, it exists as
an equilibrium of ascorbate anions, ascorbyl radicals, and
the further oxidized dehydroascorbate. The latter is
particularly good at sneaking through cell membranes
disguised as glucose. Mostly, normal cells can cope with
this <link>. While anaerobes struggle.
To increase the general effect, menadione, a slightly
banned version of vitamin K, is much better at being
oxidized by O2, and subsequently forming a cycle from
O2 <> menadione <> ascorbate <> dehydroascorbate>
This should be particularly nasty for any sensitive
anaerobes below the gum line, and a little topical
ascorbate can't be a bad thing for repairing the holes in
collagen made by the protease secreting anaerobic
Ascorbate, just fine for normal cells
[bs0u0155, Feb 18 2019]
O2 menadione ascorbate redox cycle
[bs0u0155, Feb 18 2019]
10 minutes of air kills anerobic bacteria
[beanangel, Feb 19 2019]
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||I read "Obligate anaerobes are destroyed when exposed to the atmosphere for as briefly as 10 minutes" [link]. I do not know if the oxygen you would describe would last long enough.
||Gargling with liquid oxygen should solve a lot of your problems, then.
||//a slightly banned version of vitamin K//
||Not Acrobatic Toothpaste then?
||Liquid nitrogen would be even better.
||Would liquid Helium make your gargle more high pitched?
||Nature loves it's dynamic web of evolution but i don't know whether three Vitamin C infused brushes a day, counts.
Do anaerobic bacteria get a run on their vacuoles before they die?
||How about ascorbate chewing gum, for a longer-lasting
||The combination of vitamin C and menadione has also been
investigated for use against prostate cancer, according to
Wikipedia's article on the latter, though it doesn't mention
the results. If they were good, that could be another selling
point for this toothpaste.
||//Obligate anaerobes are destroyed when exposed to the atmosphere for as briefly as 10 minutes// so stand with your mouth wide open for 10 mins a few times a day?
||Don't overdo thatif you have your mouth open all the time,
your teeth will get dry and you'll get cavities, apparently.
||Balancing a balance on underlining balances, until something is overloaded, underloaded or fulcrums aren't cleaned properly and we die.
||Those are wise words, [wjt], whatever they mean.
||Thing is, words just mean.