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Longevity Drug: ethynyl fluororapamycin

Halogenating (placing a fluorine atom at) can cause drugs to have 1000 times potency at the receptor, an ethynylization causes hundreds of times greater activity at the receptor. Combined an 8000-9000 times stronger potency per mg/dose could be possible, applied to rapamycin a drug that causes 60% greater longevity increase could create a one injection drug at humans that causes 60% greater longevity with one injection.
  [vote for,

Rapamycin is published as causing 60% greater longevity at mice.

Fluorinating drugs like corticosteroids causes them to be 1000 times more active at the receptor, and makes them less likely to be metabolized as well.

Ethynlyzing estrogen causes it to be 700 times more active as an estrogen at less than 1 microgram (hundreds of nanograms) estrogenic activity at a pill as as compared with 600 micrograms at a conjugated estrogen pill.

Combined, ethynylized fluororapamycin could be 8000-9000 times as active at the receptor. Administered as one time dose of 1 gram as a depot injection or a depot preparation like nexplanon norplant rods people getting the longevity drug treatment could live 60% longer. That is a 246 year on injection supply.

Research to do proof of concept on this could be as little as $15,000 to research 15 different molecular variants of ethynyl flurorapamycin.

Tell everyone you know, and be mention it to rich people who might want to do bespoke research to make them and their loved ones live 60% longer with one injection for a slight adjustment of which car to get.

beanangel, Aug 30 2019

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       I don't think large activity spikes in one receptor is a smart move if it unbalances all the cyclic and buffering mechanisms. 8000-9000 in all participating enzymes, I don't think so. There is going to be blow back.
wjt, Aug 30 2019

       <Obligtory Ethyl Methane Sulphonate reference/>
8th of 7, Aug 30 2019

       Oh no, he's relapsed…
notexactly, Aug 30 2019

       Actually, the patient was dead before he left the table ...
8th of 7, Aug 30 2019


       "Anti-agathics are here again"   

       "The skies above are clear again"   

       "No smoke from crematori-em"   

       Sung to the tune of Happy Days Are Here Again?   

       [8th] your talents in this respect are called for.;D
Skewed, Aug 30 2019

       [Sirolimus, also known as RAPAMYCIN, is a macrolide compound that is used to coat coronary stents, PREVENT ORGAN TRANSPLANT REJECTION and treat a rare lung disease called lymphangioleiomyomatosis. It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.   

       Sirolimus - Wikipedia]   

       So an immunosuppressant, so, take it & die much younger than otherwise from the common cold, or live a restricted life to avoid contact with any germs that's no fun at all for longer?   

       It's not sounding like a fun option either way to me?
Skewed, Aug 30 2019

       //Ethyl Methane Sulphonate//   

Skewed, Aug 30 2019

       //So an immunosuppressant, so, take it & die much younger than otherwise from the common cold, or live a restricted life to avoid contact with any germs that's no fun at all for longer?//   

       If you avoid dying of infection, then great. But a lifetime of immunosuppression will probably mean cancer will get you sooner rather than later. Rapamycin is a pretty dirty drug, it has several targets that vary in their binding affinity and even type i.e. competitive/non-competitive. There's already a fair few professionals working on derivatives, some of which I use for a fancy drug-induced dimerization technique in superresolution imaging. But, rapamycin isn't going to extend human life.
bs0u0155, Aug 30 2019

       ... unless it's a specific for a pathogen you've contracted ...
8th of 7, Aug 30 2019

       Mostly what [bs] said. I think there's reasonable evidence for *some* life extension in mice - I don't believe 60%, though. And what [bs] said about cancer.   

       But furtheralsomore, where did you get this bee in your bonnet about halogenating the hell out of everything? I don't buy the idea that it's a blanket mechanism for enhancing the potency of all drugs - I imagine it might slow down the metabolism of many, and influence (up or down) receptor binding, but beyond that it's guesswork.
MaxwellBuchanan, Aug 30 2019

       // halogenating the hell out of everything //   

       Well, you could try Astatine ...
8th of 7, Aug 30 2019

       //you could try Astaine// I always thought Ginger Rogers was the better dancer of the two.
MaxwellBuchanan, Aug 30 2019

       Bah. Sp. fixed.   

       And Gene Kelly was a better dancer.
8th of 7, Aug 30 2019

       Halo has too much cultural influence especially in people with faster frame rates.
wjt, Aug 31 2019

       I've long thought that a good way to extend longevity would be to deoxygenate the blood completely and seal the body off from encountering any more of that dangerous, corrosive gas.
nineteenthly, Sep 01 2019

       We've been experimenting on that for years, using the feline model. No actual success so far, but that doesn't necessarily mean that there is anything intrinsically wrong with the concept, and we refuse to be discouraged by a relatively small number of unpromising initial outcomes.   

       // people with faster frame rates //   

       ... but only an 8-bit CPU with limited adressing modes, and a very restricted amount of RAM.
8th of 7, Sep 01 2019


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