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First off, hi. I'm sortof new here. Second off, this isn't
so much an idea as a hypothesis...I was looking for
somewhere to bounce this around, and this seemed like
a good place...
Recent literature has associated insulin resistance in
muscle cells with interference of the insulin signaling
pathway by excess intramyocellular triglyceride (imcTG)
and fatty acid content, and the correlation between
imcTG and MIR is now well established; it has been
further postulated that imcTG is in fact, a source of
MIR, as well as an indicator.
In individuals exhibiting MIR, glucose is taken to the
liver, where it is then converted to fatty acids, rather
than being taken to the insulin-resistant muscle cells for
metabolism. If this is the case, I believe it is a
possibility that these fatty acids could somehow end up
in the the muscle cells, and thereby contribute to further
reduction of insulin sensitivity.* In this way, MIR would
itself contribute to its own progression.
*Edited to be a statement. But now it sounds like I think
I know what I'm talking about...
Comments? Questions? Accusations?
Intramyocellular lipid kinetics and insulin resistance.
[transcriptase, Jul 10 2013]
Intramyocellular lipids: maker vs. marker of insulin resistance.
[transcriptase, Jul 10 2013]
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||Welcome officially, and good luck. It's always nice to see a
lurker take the plunge.
||Prepare to take a raft of shit for this
post not being an actual halfbake. Try re-writing it as
postulation rather than inquiry; it may take some of the
||I now leave you to the tender ministrations of 'bakers who
know what you're talking about. This stuff is way out of my
||Welcome, molecular biologist!
||But, as pointed out, this is a theory rather than an
||// But now it sounds like I think I know what I'm talking
||Yep, that's how it's done. You should fit in nicely.
||What [MaxwellBuchanan] said. Theories are frowned-upon around here, unless you can connect them to an invention of some sort. To avoid the dreaded "marked for deleting", you may have to edit your main text, to add something inventive. It is possible that the Deletion Patrol will be lenient for a few days, giving you a chance to do that....
||I'm not sure that makes sense grammatically... you're saying that MIR (which I assume means muscular insulin resistance or something like that) is a bad thing, but you want it to contribute to its progression ?
||[FlyingToaster]: MIR does indeed mean muscle
insulin resistance, my apologies for not clarifying
that acronym earlier. And I don't "want" MIR to
contribute to its own progression, it's merely a
postulation as to the mechanism by which MIR
||As pointed out by [Vernon] and others, seeing as
this idea does not fit with the purpose of the site,
I think I'll just let it be "marked for deleting"...I'm
having a hard time finding any way I would
incorporate this into an invention. I have a couple
other ideas that are more "inventive".
||// I have a couple other ideas that are more "inventive".
||Post it, and they will bun...