h a l f b a k e r yTrying to contain nuts.
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KBr desensitizing skin ointment
desensitizing toothpaste works when potassium ions depolarize neurons. Could anti itch ointments have KBr to cumulative decrease itch? | |
Sensodyne toothpaste has potassium nitrate and the
potassium eventually "depolarizes" the neurons in the
tooth
nerve after about two weeks.[link]
I think it is possible that a potassium ion anti itch cream
or
other medicine (variations on hydrocortisone) Could
build up
numbness over
a couple weeks as well.
In another area, people used to take bromides (Br ion) to
replace the Cl ions at neurons to cause anti-anxiety
effects.
Perhaps both bromides and potassium could be combined
at
topical anti itch healing ointments. So KBr is the new
ingredient for anti itch/acne/cortisone-like creams.
Kno3 toothpaste "depolarizes the nerve"
http://sensodyne.co...ng-sensitivity.aspx
[beanangel, Jan 04 2018]
[link]
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One possible issue is that ion turnover in most tissues is very much faster than in places like dental nerve roots. |
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As far as I can tell, K+ and NO3- both sensitize, that's not
as counter-intuitive as it might seem. Neurons signal with
action potentials, which is a fancy way of moving from a
polarized membrane to a depolarized membrane. They
don't KEEP signalling if they stay depolarized, it's the
transition that counts. So if your treatment dramatically
favors the polarized OR depolarized position you inhibit
signalling. So as far as I can tell, swapping NO3- for Br- is
moving away from a synergistic mechanism. Now,
whether it's a good idea to promote permanently
depolarized neurons... that sounds like a recipe for dead
neurons, or at least retreating processes. A better
strategy might be to promote the polarized state, so
bioenergetic support, decreasing Ca2+/K+ a more
reducing redox state. |
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All the toothpastes/mouthwashes etc seem to do the
opposite, Big Ca2+, low Mg2+, Fl- (glycolysis inhibitor)
bicarbonate and even H2O2. Further reading suggests that
the nerve have cold receptors... so obviously we put the
cold-receptor agonist menthol in there.. |
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hmm, maybe remove the menthol, add Mg2+, maybe
cinnamon derivatives as TRPV inhibitors, maybe even
some pharmacological Ca2+-channel blockers. A super
reducing environment is just as brutal to bacteria as an
oxidizing one, shame I can't think of a safe reducing agent
that doesn't smell nasty. |
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Hydrogen ? Cheap, ubiquitous, colourless, odourless ... the
Phillip Schofield of reactive gases ... |
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//Hydrogen ? Cheap, ubiquitous, colourless, odourless// |
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while difficult to dissolve in a toothpaste or mouthwash, you
could fill your mouth with it and then simply walk around all
day with your mouth pointing directly downward. No, I think
2-mercaptoethanol is the one for this gig. Cheap, effective,
and regular bad breath will suddenly become a footnote on
the smell landscape. |
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//2-mercaptoethanol// Ah, the old Chanel Number 13. |
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I'm thinking a cream or ointment for the skin. Perhaps
liposomes could deliver more ions and minimize ion
concentration at the surface |
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