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causing immune system to lose its receptors for a certain illness
  [vote for,

White blood cells have receptors that discover illnesses encountered, but as people age, there are many false alarms causing autoimmune diseases.

Our research discovered in its second half how to cause the body to eventually lose its immunity to specific biochemical markings.

Once that is done diabetes type I and many other illnesses can be treated...

pashute, Apr 30 2018

vaguely related https://www.ncbi.nl...gov/pubmed/23902557
[pashute, Apr 30 2018]

strongly related.... https://www.monash....immunology-ideology
hmm.. interesting read [pashute, Apr 30 2018]

perhaps a start? https://onlinelibra...f/10.1002/art.11072
[pashute, Apr 30 2018]

Flatliners https://www.imdb.co...82/?ref_=fn_al_tt_2
Restart from cold. [8th of 7, May 02 2018]


pashute, May 01 2018

       Umm, sure, but how exactly do you propose to "reset" the immune system?
MaxwellBuchanan, May 01 2018

       chlorine. Lots of chlorine. Getting it to start again could be tricky.
RayfordSteele, May 01 2018

       Isn't there a button on the back somewhere?
pertinax, May 02 2018

       So, I read the middle link, and the new fact in it is //the T-cell receptors associated with type 1 diabetes can bind to the MHC in the opposite orientation [i.e. opposite to the way they usually bind].//   

       I'm not doubting that it's important in some way, but how do you get from there to resetting the immune system?
pertinax, May 02 2018

       // Isn't there a button on the back somewhere? //   

       Depends which version you have. Maybe there's an OBD II port somewhere ?   

       We suggest powering everything off, pulling all the breakers, waiting five minutes, then powering the systems up again one at a time checking each one for faults as you go. <link>
8th of 7, May 02 2018

       [marked-for-deletion] magic
Loris, May 02 2018

       The problem with resetting the immune system is that you'd have to somehow repeat what happens before birth.   

       The immune system starts out with gazillions of random targets. Before birth, any immune cells that recognise anything get killed. Hence, any immune cells targetting normal body components should get killed off. This is your main protection against autoimmunity. So, when you're born, your immune system consists of cells that recognise a random selection of "non-you" things.   

       When you get an infection, some of the cells will happen to recognise the infectious agent, more or less. Those cells then proliferate, but they also evolve in an attempt to make the recognition stronger.   

       Unfortunately, if an infectious agent resembles a normal body component, then the "evolution" stage can lead to immune cells that recognise that body component as well as the infectious agent. Other factors can also trigger immune cells to mistakenly evolve towards targetting normal body components. Either way, the result is an autoimmune disease.   

       Once autoimmunity gets started, it's very difficult to stop. The cells responsible for it have no way to know they're targetting your own body - they just think they're fighting an infection, and so they proliferate and get more and more aggressive. The whole "friend/foe" business can only happen before birth, when there are no "foes". After that, it's very difficult.
MaxwellBuchanan, May 02 2018

       //Once that is done diabetes type I and many other illnesses can be treated...//   

       That wouldn't be all you could do with it, you could use any old animal organ you wanted for transplants. Lost an arm? graft on a Gorillas.
Skewed, May 02 2018

       This made me think of an immune system with brains, well a matrix with some tiers of filtering. Bad, bad but good; good, bad, good but also good.   

       This would need an antibody to a bound antibody already bound to an antibody bound complex and a very discerning white cell or groups of white cells. Far from the normal, antibody bound is bad, engulf.   

       No metaphysical logic though, just the intrinsic fabric of the universe's pieces recursing up shape wise to say what's good and what's bad at a higher scale.
wjt, May 02 2018

       Clearly what’s needed is a government immunity system interface to decide what a good cell is and what a bad one is. Maybe in IBM Doors.
RayfordSteele, May 02 2018

       there's a difference between impossible and very difficult. And that's the diff between magic or wishful thinking and the beginning of a discussion on an idea, that isn't being discussed because people think it's impossible.   

       The second link is claiming that there may be a way to develop T cells that work regularly BUT can be controlled, via some extra drug, which can turn them on or off. The link claims also that established knowledge about the T cells formerly considered to be complete is now being re-visited.
pashute, May 07 2018

       //can be controlled//   

       Are you sure that's what it says? The way it reads to me, receptors in the different orientations behave in the same way. So, if you wanted to use the orientation somehow as a control mechanism, it would be like a switch that toggled between ON and ON, with no OFF state. How would that help?
pertinax, May 08 2018


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