The bowling ball is also a quadcopter inside a ball shaped mesh.
The flying pins arrange themselves automatically by some sort of mechanism and when hit by the quadcopter ball you "roll" at them, they fall out of the air.
The ball returns after every throw, and after two shots they reset just like
Except in the air.
You could also have it be more like a football you throw at a big target grid in the sky. The basic idea is knocking down drones arranged in various patterns, the bowling pins are one, but maybe a clown face where you knock out the teeth. The possibilities are un-limitless.