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Drinkable perfluorocarbon blood substitute prevents SIDS

drinkable perfluorocarbons reach the circulatory system where they ameliorate illness and could prevent SIDS
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There are commercial oxygen carrying blood replacement fluids called perfluorocarbons [link].

If you drink oxygen dissolving perfluorocarbon (blood substitute) does it get absorbed to the circulatory system with your circulatory fluids? Wikipedia says it does.

Drinking perfluorocarbons could be an oral therapy for people with pulmonary (COPD) and heart oxygenation difficulties. It may also be a way to voluntarily increase athletic performance. One of the perfluorocarbons at the wikipedia [link] looks polar to me, and the other looks nonpolar. Making a more highly polar version could cause some uptake from oral dosing.

Another oral dosing approach is to put the perfluorocarbon in liposomes which do pass through the GI tract to have various contents absorbed.

Also, it might be possible to use some hypertransport of imbibed fluids technology like ORT (Oral rehydration therapy) to preferentially transport the perfluorocarbon to the circulatory system.

Preventing SIDS (sudden infant death syndrome) with oral perfluorocarbons: When the baby at the 2-6th month highest risk interval is fed perfluorocarbon It enters the Baby's circulatory system, imaginably increasing oxygen carrying capacity 40- 80%. Then if the baby spontaneously stops breathing (SIDS(?)) it has 40-80% longer to restart its breathing.

Reading wikipedia suggests you get almost full coverage if you have babies drink it from just age 2 months to 6 months

One benefit to babies from preventing SIDS, along with being alive, is that precluding and curing SIDS makes it so people can start putting toys and blankets back in cribs providing a snugglier environment for the baby.

beanangel, Apr 28 2021

perfluorocarbon https://en.wikipedi...rfluorocarbon_based
[beanangel, Apr 29 2021]

IV perfluorocarbons rescue body tissue (lung) from ischemia https://journals.pl...ournal.pone.0087826
[beanangel, Apr 29 2021]

perfluorocarbons are just $5-$8/Kg https://www.alibaba...rbon&viewtype=&tab=
Not medical grade, medical grade is $1000/Kg [beanangel, Apr 29 2021]

Perflourocarbons are used in artificial blood. https://science.how...20like...%20More%20
[Voice, Apr 30 2021]

Side effects of blood substitutes https://www.comicsk.../bizarro/2021-05-01
Bunny, eyeball, pipe, dynamite, K2 [a1, May 01 2021]

[link]






       See “Goofballs” - oxygen containing pills so you don’t need to breathe.   

       The Sirens of Titan
Kurt Vonnegut, Jr (1959)
a1, Apr 28 2021
  

       Bone - tentative - unless you show research proving adequate O2 can get into blood from digestive track without causing other harm, and you also have a way to remove CO2.
a1, Apr 28 2021
  

       [a1] the perfluorocarbon does not actually carry a load of oxygen from being swallowed. It joins the circulatory fluids and then carries extra oxygen the baby breathes in through its lungs. This is sort of like when athletes transfuse their own blood back into themselves so they have say 140% oxygen carrying capacity compared with 100%.
beanangel, Apr 29 2021
  

       So perfluorocarbon can hand off oxygen to heme?
Voice, Apr 29 2021
  

       Sleeping with the mother is the best thing for the baby.
Voice, Apr 29 2021
  

       [beanangel] can you cite research showing any “drinkable” perfluorocarbon can increases blood oxygen without other harmful effects?
a1, Apr 29 2021
  

       [a1] The wikipedia link says, "PFC solutions can carry oxygen so well that mammals, including humans, can survive breathing liquid PFC solution, called liquid breathing."
beanangel, Apr 29 2021
  

       None of these are drinkable, or did I miss something?
a1, Apr 29 2021
  

       [a1] that is the new to me idea part: that if you can rinse your lungs with it it is likely safe to drink. Thanks for asking because I got to incorporate the part about ORT in the description.   

       1) why do I believe it will diffuse through the GI tract to replace plasma volume; will it get peed out?   

       reply to 1) a perfluorocarbon is actually kind of like a fluorinated branched alkane, if you want it to be even more polar than it is you just change a couple atoms on it. Making a polar version of perfluorocarbon could cause it to avidly pass from the GI tract to the circulatory system   

       Also, you might have heard of Oral rehydration therapy, they can mix some sugar and salt into water and it becomes like 160% more rapid at passing into the body than freshwater. I think ORTPerfluorocarbon solutions are possible, so that could make it 160% better at getting absorbed into the body than perfluorocarbon alone
beanangel, Apr 29 2021
  

       //if you can rinse your lungs with it it is likely safe to drink// - what?!
hippo, Apr 29 2021
  

       injecting perfluorocarbons causes sufficient increased oxygen carrying capacity to keep lab mammals alive by circumventing ischemia [link]   

       So, babies drinking perfluorocarbons makes them asphyxia resistant and there is more time for their breathing to automatically restart without injury to the baby.
beanangel, Apr 29 2021
  

       You first. Have your next of kin let us know where to send flowers.   

       Look at the elimination path in liquid breathing experiments as well as in IV treatments. Zero support your “new idea” that drinking it would somehow get it into the blood for beneficial effect. Depending on the compound, it’ll either be inert or actively toxic.
a1, Apr 29 2021
  

       //is fed perfluorocarbon It enters the Baby's circulatory system,//   

       Animal life would be in pretty bad shape if everything we ate just ended up in the circulatory system. We have a whole organ system to control that process. Unmodified perfluorocarbons aren't water soluble, and as a artificial compound there won't be a receptor or transporter. So, it will likely just come out the other end with all the other stuff the body doesn't know what to do with.   

       //perfluorocarbon can hand off oxygen to heme?// It should happen in both directions depending on the pO2. You also need some intervening medium like water for the O2 to move between.   

       //Making a polar version of perfluorocarbon could cause it to avidly pass from the GI tract to the circulatory system//   

       No, we have cell membranes that are impermeable to polar molecules. Each and every polar molecule, and others including water, has to have a specific protein transporter. Take lactose, it's composed of two monosaccharides for which there are transporters. In lactose intolerant people, they can't split it into monosaccharides and as such, it hangs around, acting osmotically to hold water in the lumen of the bowel.   

       // Oral rehydration therapy, they can mix some sugar and salt into water and it becomes like 160% more rapid at passing into the body than freshwater.//   

       Well, we know the mechanism for this, and it doesn't apply. Our bodies don't control the flow of water into and out of cells, it just moves passively through channels called aquaporins. What we control is the flux of ions, mainly Na+ and K+, if you move those around then water follows osmotically. Adding sugar just adds some extra energy to power the Na+/K+ pumps.   

       // //if you can rinse your lungs with it it is likely safe to drink// - what?!//   

       There's some logic there, PFCs aren't toxic as far as we know. And the digestive system is a lot less fussy about things than the lungs. You can perform an experiment with two fresh cups of tea, drink one, breath the other and see which one is better tolerated.   

       //Look at the elimination path in liquid breathing experiments as well as in IV treatments.//   

       Transport is the biggest problem. You're putting liquid (well, they have to make stabilized emulsions) into an air handling system, and that system is tidal. The other main problem is the O2 binding kinetics. PFCs have a linear relationship between O2 binding and pO2. Hemoglobin is much cleverer than that, it has a huge non-linearity meaning it will grab/dump O2 in specific sweet spots that correlate with O2-rich lungs, O2-poor tissue. The O2 affinity is also modified by useful things like pCO2 and pH. It's all very neat.   

       What might be interesting, is that you could definitely put PFCs through the bowel. The bowel is extremely well vascularized and is pre adapted for absorbtion and it's not (usually) tidal. If you had someone with serious lung problems, maybe you could pump artificial blood through the bowel and get O2 in that way while the lungs recover. That way you're handling liquids with a liquid handling organ. It might be less problematic than forcing higher and higher O2 concentrations into already damaged lungs. O2 is nasty stuff at high concentrations.
bs0u0155, Apr 29 2021
  

       Interesting? I think you're just blowing smoke up his arse there.
a1, Apr 29 2021
  

       More content at the idea, it now includes, "One of the perfluorocarbons at the wikipedia [link] looks polar to me, and the other looks nonpolar. Making a more highly polar version could cause some uptake from oral dosing.   

       Another oral dosing approach is to put the perfluorocarbon in liposomes which do pass through the GI tract to have various contents absorbed."
beanangel, Apr 29 2021
  

       //perfluorocarbon in liposomes which do pass through the GI tract to have various contents absorbed.//   

       Liposomes get you through one cell membrane. Now you have a load of redox active, non-metabolizable insoluble molecules in the cytoplasm of the 1st layer of cells. That's a very good way of making them toxic, but it doesn't get them into the blood, and even if it did, they'd be insoluble.
bs0u0155, Apr 29 2021
  

       I knew alibaba would come into it eventually. But where are the frickin' lasers?!?
a1, Apr 29 2021
  

       [a1] good idea about the lasers, it is just possible a really bright flash of white light that illuminates even a sleeping baby's eyes with light so bright it startles them could restart breathing. like, could, I do not have any idea!
beanangel, Apr 29 2021
  

       You forgot to mention how this will also cure diaper rash, the dreaded lurgy, and covids 19 through 37.
a1, Apr 30 2021
  

       I have not been here often lately, but I can still detect a [beanangel] idea solely by the title at a glance ;-)
normzone, Apr 30 2021
  

       //you're just blowing smoke up his arse//   

       That'll be hard to absorb into the lungs.
pertinax, May 01 2021
  
      
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