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rebound-beneficial drugs

Use drug rebound (very unlike, but a little like tolerance) to cause opposite-effect rebound, making diseased or improvable tissue effectively drugged and treated
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Some pharmaceutical drugs produce a rebound effect: A blood pressure medication might cause less of the naturally occurring blood pressure reducing biochemicals to be produced.

What if you gave people metabolites of drugs to heighten that bodywide opposite response even while you were medicating a problem locally?

One possibility is using metabolites of drugs as source chemicals.

Dosing the person with the metabolites at nonessential areas would cause 90% of the body's response to the molecule would be to make a "make more useful stuff" rebound effect instead of "make less useful stuff" rebound response.

You could give an opposite effect drug to an uninvolved large body compartment like the GI-tract: One example is sending dopamine reducers to only GI tract neurons. That then causes the body to upregulate dopamine production globally, causing the brain to produce more dopamine as it “rebounds” from the GI-tract-only dopamine reducer. This causes better mood and sense of reward from the increased brain dopamine. A happy pill.

One reason to use metabolites as drugs is that they might occupy activity-producing receptors with much less produced activity, sort of blocking the receptor.

Other new drugs that might work this way:

At dermatitis or inflammation, could you heighten something like a dermatitis chemical response (without any actual tissue harm) at something like the large, rapidly renewing GI-tract’s volume? That causes the entire body to produce a larger amount of inflammation and/or dermatitis reducing chemicals. That would work on broad or diverse skin areas. This could be a pill to reduce or cure atopic dermatitis.

Some dopamine drugs are psychiatric drugs. An anti- schizophrenic drug: a GI-tract dopamine rebound producing molecule could upregulate or downregulate the body's chemicals that affect D(1,2,3,4) receptors or the receptor affinity modifying chemicals, with all the side effects at only the GI tract and not at the brain. That minimizes sedation and fuzzy-headedness from psychiatric drugs. This could also work with serotonin and antidepressants.

Cotinine is a metabolite of nicotine. It has a calming effect. I do not know if this if from receptor blockade or not.

A nootropic (intelligence increasing) drug that works this way might be a big dose of active-only-at the GI-tract cotinine that causes global bodywide up-responsiveness of the smartness producing nicotinic acetylcholine receptors, notably at the brain, increasing functional intelligence.

beanangel, Jan 13 2019


       holistic homeopathy ?
FlyingToaster, Jan 13 2019

       This is fine, as long as you remember to tell each molecule to go and stay where you want it.
MaxwellBuchanan, Jan 13 2019

       [mb] Rather weirdly, whatever is in food (or an oral drink) likely has a much higher concentration at the GI tract than in blood, and much higher than in any particular tissue. It is possible to imagine the concentration difference between GI tract and brain tissue might be more than an order of magnitude. Maybe three!   

       One possibility for a rebound drug that does not soak in to the rest of the body is to construct it so that it degrades rapidly in the bloodstream from enzymes there. Perhaps Monamine oxidase or something. Someone who knows their blood enzymes could likely name many enzymes that could work on enzyme-friendly customized versions of the molecule.
beanangel, Jan 13 2019


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